Modeling Ion Channel Kinetics with Parameter Constraints

Markov Modeling of Conformational Kinetics of Cardiac Ion Channel Proteins

Fractal methods to analyze ion channel kinetics.

We describe the traditional nonfractal and the new fractal methods used to analyze the currents through ion channels in the cell membrane. We discuss the hidden assumptions used in these methods and how those assumptions lead to different interpretations of the same experimental data. The nonfractal methods assumed that channel proteins have a small number of discrete states separated by fixed ...

Fractional diffusion modeling of ion channel gating.

An anomalous diffusion model for ion channel gating is put forward. This scheme is able to describe nonexponential, power-law-like distributions of residence time intervals in several types of ion channels. Our method presents a generalization of the discrete diffusion model by Millhauser, Salpeter, and Oswald [Proc. Natl. Acad. Sci. U.S.A. 85, 1503 (1988)] to the case of a continuous, anomalou...

Optimal Estimation of Ion-Channel Kinetics from Macroscopic Currents

Markov modeling provides an effective approach for modeling ion channel kinetics. There are several search algorithms for global fitting of macroscopic or single-channel currents across different experimental conditions. Here we present a particle swarm optimization(PSO)-based approach which, when used in combination with golden section search (GSS), can fit macroscopic voltage responses with a...

Modeling of Boron DeactivatiodActivation Kinetics During Ion Implant Annealing

AbsfrucfBoron Transient Enhanced Diffusion (TED) is characterized by enhanced tail diffusion coupled with an electrically inactive immobile peak associated with the clustering of boron in the presence of excess interstitials. A consistent model for process simulation has to account for the formation of a variety of agglomerates associated with the excess point defect concentrations following io...